31/03/2013
Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now. A team of investigators from nine institutions have discovered how ATP – the body's main fuel source– is released as the neurotransmitter from sweet, bitter, and umami, or savory, taste bud cells. The CALHM1 channel protein, which spans a taste bud cell's outer membrane to allow ions and molecules in and out, releases ATP to make a neural taste connection. The other two taste types, sour and salt, use different mechanisms to send taste information to the brain.
Pictured here: Taste buds in a circumvallate papilla in a mouse tongue with types I, II and III taste cells visualized by cell-type-specific fluorescent antibodies. More info: http://bit.ly/W5J4qK